Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 22608312
Gene Name PLCD3
Condition Endometriosis
Association Associated
Sex Female
Associated genes PLCB3, PLCD1, PLCB1, PLCD3
Other associated phenotypes Endometriosis
Expression of phosphoinositide-specific phospholipase C enzymes in normal endometrium and in endometriosis.

Fertil Steril. 2012 Aug;98(2):410-4. doi: 10.1016/j.fertnstert.2012.04.020. Epub

Lo Vasco, Vincenza Rita| Leopizzi, Martina| Chiappetta, Caterina| Businaro, Rita| Polonia, Patrizia| Della Rocca, Carlo| Litta, Pietro

Department of Sensitive Organs, Policlinic Umberto I, Sapienza University, Rome, Italy. ritalovasco@hotmail.it

OBJECTIVE: To delineate the panel of expression of phosphoinositide-specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis. DESIGN: Clinical/experimental study. SETTING: University. PATIENT(S): Healthy donor woman and endometriosis-affected woman. INTERVENTION(S): Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses). MAIN OUTCOME MEASURE(S): Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC beta1, PI-PLC beta2, PI-PLC beta3, PI-PLC beta4, PI-PLC gamma1, PI-PLC gamma2, PI-PLC delta1, PI-PLC delta3, PI-PLC delta4, PI-PLC epsilon, PI-PLC eta1, and PI-PLC eta2. RESULT(S): PI-PLC beta1, PI-PLC beta3, PI-PLC delta1, and PI-PLC delta3 enzymes were detected, although differently expressed in normal and endometriosis tissues. CONCLUSION(S): The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis.

Mesh Terms: Adult| Endometriosis/*enzymology/genetics/pathology| Endometrium/*enzymology/pathology| Female| *Gene Expression Regulation, Enzymologic| Humans| Phosphoinositide Phospholipase C/*biosynthesis/genetics|DA 2012/10/12 06:00